01/2021
Content
Igor Richter, Josef Dvořák, Jiří Bartoš
Lenka Jakubíková
Combination of nivolumab and ipilimumab in the first‑line treatment of non‑small cell lung cancer
David Vrána
Ondřej Bílek
The role of concomitant chemoradiotherapy in the treatment of non‑small cell lung cancer
Jaromír Roubec, Jaromír Richter
Cemiplimab in the treatment of non‑melanoma skin tumors
David Vrána
Adam Wendrinski
Apalutamide – a new treatment option for prostate cancer
Jaromír Richter
News in the treatment of metastatic HER2 positive breast cancer
Lucie Reifová
Current treatment options in diffuse large B‑cell lymphoma
David Belada
Gastrointestinal stromal tumor in 2020 or suddenly a lot of news
Jan Novotný
Prevention of osteonecrosis of the jaw in the treatment with bone modifying agents
Lucie Reifová
The story of unusual diffuse large B‑cell lymphoma – case report
Andrea Janíková
Petr Zůna
Subsolid lung nodulus in CT imaging in a female patient with colorectal carcinoma – case report
Vladimír Červeňák, Alena Berková, Zdeněk Chovanec, Jiří Vaníček, Tomáš Hanslík, Sabina Svobodová
Sternal chondrosarcoma – a case report
Zdeněk Chovanec, Michal Reška, Alena Berková, Vladimír Červeňák, Jiří Veselý, Zdeněk Dvořák, Tomáš Hanslík, Adam Peštál, Vadym Prudius, Ivan Čapov
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Epidermal growth factor receptor – its importance, diagnosis and development of treatment in non‑small cell lung cancer
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Combination of nivolumab and ipilimumab in the first‑line treatment of non‑small cell lung cancer
Metastatic non-small cell lung cancer represents a disease with poor prognosis. Introducing tyrosine kinase inhibitors of specific mutations into daily practice improved the prognosis of a group of patients, however for majority of the patients before the era of immunotherapy the chemotherapy was the only option. Several molecules working as immunotherapeutic agents have proven their effectivity and safety in the first and second line of palliative treatment of the lung cancer. Recently the combination of nivolumab with ipilimumab was introduced into the clinical practice based on the CheckMate 227 and CheckMate 9LA trials. Combined immunotherapy with nivolumab and ipilimumab represents a new treatment option for patients with non-small cell lung cancer without specific mutations regardless of programmed cell death-ligand 1 (PD-L1) expression. Registration in the Czech Republic as well as health care reimbursement is unfortunately missing at this moment for this new combination.
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