Treatment strategies in patient with gastric and gastroesophageal junction tumors

06/2018

MUDr. Peter Grell, Ph.D.; MUDr. Radka Obermannová, Ph.D.

Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno

SUMMARY

Gastric and gastro-oesophageal junction cancers are aggressive diseases, and only 25 % of patients with early stage disease achieve a long-term survival. The modern multimodal approach to treatment nearly doubled survival in these patients. The primary requirement for successful treatment is performing adequately radical resection in centers specialized in these challenging surgeries. In gastric cancer, the use of perioperative chemotherapy is recommended as a standard of care. The most effective regime in this approach is FLOT chemotherapy. In gastro-oesophageal junction carcinomas, in addition to perioperative therapy, neoadjuvant chemoradiotherapy appears to be appropriate strategy, mostly in cases with locally advanced carcinomas where tumor regression is required in order to perform an R0 resection.

KEY WORDS

gastric cancer, gastro-oesophageal junction cancer, perioperative chemotherapy, neoadjuvant chemoradiotherapy