Terapeutický význam mikrosatelitové nestability u adenokarcinomů tlustého střeva

05/2018

MUDr. Stanislav John

Klinika onkologie a radioterapie LF UK a FN, Hradec Králové; Ústav lékařské biologie a genetiky LF UK, Hradec Králové

SUMMARY

Colorectal carcinoma is heterogenous disease. Methods of molecular testing reveals new alterations, often without better understanding. However, some of these molecular tests, such as KRAS/NRAS or BRAF mutations, are already projected into daily practice. Microsatellite instability represents one of these detectable changes. Nor it helps us to decide on adjuvant chemotherapy, but it is increasingly important with the advent of drugs that affect the immune system.

KEY WORDS

colorectal carcinoma, microsatellite instability