Prognostic significance of primary cilia in relation to selected parameters of the tumor microenvironment of clear cell renal cell carcinoma
04/2020
MUDr. Aneta Rozsypalová1; MUDr. Blanka Rosová2; Mgr. Alžběta Filipová, Ph.D.3; MUDr. Dimitar Hadži Nikolov, Ph.D.4; Mgr. Renata Chloupková5; MUDr. Igor Richter, Ph.D.1,6; MUDr. Jan Prokš1; prof. MUDr. Radoslav Matěj, Ph.D.2; prof. MUDr. Roman Zachoval, Ph.D.7; prof. MUDr. Bohuslav Melichar, Ph.D.8; doc. MUDr. Tomáš Büchler, Ph.D.1; doc. MUDr. Josef Dvořák, Ph.D.1
1 Onkologická klinika 1. LF UK a Thomayerovy nemocnice, Praha
2 Ústav patologie a molekulární medicíny 3. LF UK a Thomayerovy nemocnice, Praha
3 Katedra radiobiologie, FVZ, Hradci Králové, UO, Brno
4 Oddělení patologie, Oblastní nemocnice Kolín
5 Institut biostatistiky a analýz, LF MU, Brno
6 Onkologické oddělení, Krajská nemocnice Liberec a.s.
7 Urologická klinika 3. LF UK a Thomayerovy nemocnice, Praha
8 Onkologická klinika, LF UP a FN Olomouc
SUMMARY
The presence of primary cilia, programmed cell death protein-1 receptor (PD-1) expression and intraepithelial CD8+ TIL (tumor infiltrating lymphocytes) expression were retrospectively evaluated in tumor tissue blocks of the resected specimens of the kidney in 104 patients with clear cell renal cell carcinoma. Median overall survival (OS) was significantly longer in patients with lower frequency of primary cilia (<0.002) than in patients with higher frequency of primary cilia (>0.002) (p<0.001). Median OS was significantly longer in patients with lower (<25%) CD8+ TIL expression than in patients with higher (>25%) CD8+ TIL expression (p=0.006). Median OS was significantly longer in patients with lower (<25%) PD-1 expression than in patients with higher (>25%) PD-1 expression (p=0.006). The present study provides the first data on the potential association and combined prognostic significance of frequency of primary cilia, CD8+ TIL expression and PD-1 expression in patients with clear cell renal cell carcinoma.
Key words
clear cell renal cell carcinoma, primary cilia, programmed cell death receptor 1 (PD-1), CD8+ tumor infiltrating lymphocytes
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