Oral vinorelbine in the treatment of non‑small cell lung cancer – case reports
MUDr. Lenka Jakubíková, Ph.D.
Klinika nemocí plicních a tuberkulózy LF MU Brno
Vinorelbine is a second generation semisynthetic vinca alkaloid that has a low affinity for neurotubules, resulting in lower neurotoxicity. Vinca alkaloids are mitotic poisons that prevent the proper formation of microtubules by binding to tubulin. They cause depolymerization of microtubules and dissolution of the mitotic spindle, thereby blocking cell division and causing damage to other processes depending on the proper functioning of the microtubules. In oncology vinorelbine has a wider use, especially in metastatic breast cancer and non-small cell lung cancer, where it is applicable at all stages of non-adjuvant and palliative treatment.
vinorelbin, non-small cell lung cancer
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