Molecular classification of endometrial cancers


Doc. MUDr. Jiří Presl, Ph.D.1; RNDr. Tomáš Vaněček, Ph.D.2; prof. MUDr. Michal Michal2; prof. MUDr. Jiří Bouda, Ph.D.1; MUDr. Jan Kosťun, Ph.D.1; MUDr. Pavel Vlasák1; MUDr. Petr Straník1

1 Gynekologicko porodnická klinika LF UK a FN Plzeň

2 Bioptická laboratoř s.r.o., Plzeň



The basis for the diagnosis of endometrial carcinoma is histopathological morphology. Since 1983 we used Bokhman classic division of endometrial cancer on two relatively wide groups of tumors different in pathogenesis. This classification meets the didactic purpose, provides easy orientation for epidemiological data, but is not suitable for patient stratification. This division is carried out wide overlap of clinical, pathological and molecular tumor features. The Cancer Genome Atlas (TCGA) project classifies endometrial tumors into four groups based on molecular genetic features. Integration of the histopathological findings along with molecular classification appears to be the best approach for evaluating each individual tumor.


Key words

endometrial carcinoma, molecular classification, POLE mutation, mismatch repair deficient tumors (MMRd), non specific molecular profile (NSMP), TP53 mutation



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