Localization of right/left side of colorectal carcinomas and its importance in prognosis and therapy disease
RNDr. Ing. Bc. Libor Staněk1,2,3, prof. MUDr. Robert Gürlich, CSc.3, doc. MUDr. Petra Tesařová, CSc.2
1 Ústav patologie 3. LF UK a FN Královské Vinohrady, Praha
2 Onkologická klinika 1. LF UK a VFN, Praha
3 Chirurgická klinika 3. LF UK a FN Královské Vinohrady, Praha
Colorectal cancer is a serious global disease with high incidence and mortality. With the development of diagnostics in molecular oncology, we try to find predictive and prognostic factors in the search for the most effective therapy. At present, it is a molecular testing of tumors prior to considering anti-EGFR therapy. The latest available studies, however, show that the carcinoma located in the right part of the intestine has a lower sensitivity and response to this treatment than the carcinoma on its left. The essence of this phenomenon remains a question. If these changes can be identified, they can be used to optimize therapy.
colorectal carcinoma, right-sided localization, prognosis of disease, therapy, molecular diagnostics
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