Laboratory aspects of human papillomavirus testing

01/2017

RNDr. Kateřina Sieglová, RNDr. Hana Vošmiková, doc. MUDr. Jan Laco, Ph.D., prof. MUDr. Ivo Šteiner, CSc.

Fingerlandův ústav patologie LF UK a FN Hradec Králové

SUMMARY

Human papillomavirus (HPV) has been known as the main etiological factor of cervical carcinoma al ready in 1983. Since then, HPV is recognized in relation with carcinomas of other organs of anogenital tract and also of the head and neck region. Recently, it became obvious that HPV-associated squamous cell carcinomas differ significantly from the HPV-negative ones - in the epidemiology, biological behavior and prognosis. Therefore, HPV testing of tumor tissue becomes clinically important. The reis a number of methods for HPV detection, with varying requirements for the biological material and also for their sensitivity, validity and cost. According to these differences, it is important to select optimal method for HPV detection.

KEY WORDS

human papillomavirus, HPV testing, squamous cell carcinoma