Incidence and treatment of bone metastases in urological tumors


MUDr. Jana Katolická, Ph.D.

Onkologicko-chirurgické oddělení LF MU a FN u sv. Anny, Brno



Metastatic bone disease is commonly seen with urogenital cancer types - notably those with prostate (85%) and kidney (40%). Bone-targeted agents - bisphosphonates and denosumab - are potent inhibitors of bone resorption for prevention of skeletal-related events in patients with solid tumors. In a phase III study, denosumab significantly delayed skeletal-related events compared with zoledronic acid in patients with metastatic castration resistant prostate cancer and renal cancer. In addition, denosumab showed superior effects on pain and health-related quality of life in these patients.


Key words

skeletal-related event, bisphosphonates, denosumab



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