Human papillomaviruses and their role in the etiopathogenesis of malignant tumors

01/2017

Doc. MUDr. Jan Laco, Ph.D.

Fingerlandův ústav patologie, LF UK a FN Hradec Králové

SUMMARY

Human papillomaviruses, most commonly transmitted by sexual intercourse, are important pathogens, which significantly contribute to the formation of benign mucocutaneous lesions, e.g., squamous cell papillomas, condylomas, and warts, and of malignant tumors of anogenital and head and neck areas. They are the most important risk factors for cervical, vaginal and anal carcinomas, and they also play a role in the development of a subset of vulvar and penile carcinomas. In head and neck area, the are strongly associated with oropharyngeal carcinoma, mostly affecting palatine tonsils and root of tongue, and with a subset of sinonasal carcinomas.

KEY WORDS

human papillomaviruses, malignant tumors, anogenital carcinomas, head and neck carcinomas, squamous cell carcinoma