Health‑threatening interactions of phytopharmaceuticals and oncological treatment


PharmDr. Šárka Kozáková, MBA1,2; Mgr. Vojtěch Ondra1,3; MUDr. Jana Halámková, Ph.D.4

1 Ústavní lékárna, Masarykův onkologický ústav, Brno

2 Farmakologický ústav LF MU, Brno

3 Ústav humánní farmakologie a toxikologie FaF VFU, Brno

4 Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno



Around 30% of patients use food supplements and phytopharmaceuticals in potentially dangerous combinations during systemic cancer treatment. Natural substances may interfere with metabolic enzymes and transport proteins, thereby disrupting drug metabolism. In this review, we will focus on the most commonly used phytopharmaceuticals and medicinal plants, their impact on cancer treatment and the possible serious consequences that they may cause to patients.


Key words

phytopharmaceuticals, oncological treatment, interaction, medicinal plants, food supplements



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