Current treatment management of metastatic HER-2+/HER-2- breast cancer


MUDr. Nikol Rušarová1,2, MUDr. Marie Bartoušková1, doc. MUDr. David Vrána, Ph.D.1

1. Onkologická klinika FN Olomouc

2. LF UP, Olomouc



Breast cancer is the most frequently diagnosed cancer and despite the gains in early detection, up to 5 percent of women are diagnosed with metastatic disease at the time of first presentation. Due to development of new molecules breast cancer is now a chronic disease, while metastatic disease is still incurable. It is a heterogeneous diverse disease composed of several biologic subtypes that have distinct behaviors and responses to therapy.


Key words

breast cancer, trastuzumab, pertuzumab, chemotherapy, endocrine therapy, everolimus, inhibitors CDK 4/6, fulvestrant



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