Trifluridine/tipiracil therapy with long‑term effect in the patient with primarily metastatic colorectal cancer – case report


Doc. MUDr. Martina Kubecová, Ph.D.

Radioterapeutická a onkologická klinika 3. LF UK a FN Královské Vinohrady, Praha



A 71-year-old physician-surgeon in excellent condition, working full-time, with multiple locally advanced colon cancer and synchronous metastatic liver disease, was treated with subtotal colectomy and microwave ablation of liver lesions in 2015. Subsequent systemic therapy was difficult to tolerate, bevacizumab monotherapy only. He was treated with radiotherapy for progression in the liver 2016. Further progression in the liver in 2017 was solved by systemic therapy (irinotecan, cetuximab). For further progression in liver in February 2018, we have used trifluridine/tipiracil therapy, which the patient is still on (February 2020 - 28th cycle). Process stabilization with excellent tolerance has been achieved. The patient is without any problems, still working full-time.


Key words

colorectal cancer, liver metastasis, systemic therapy, trifluridine/tipiracil



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