STRN‑ALK fusion, rare variant of ALK gene – case report
MUDr. Jaromír Roubec, Ph.D.; MUDr. Jaroslav Krátký
Nemocnice AGEL Ostrava-Vítkovice Komplexní onkologické centrum, Nový Jičín
In connection with their own case report, the authors discuss the issue of rare mutations in the gene for anaplastic lymphoma kinase (ALK), known mechanisms of increased tumorigenesis of such mutated non-small cell lung cancer tumors and the possibilities of their therapeutic management using tyrosine kinase inhibitors. Literature sources and documented cases of a rare STRN-ALK fusion mutation are presented.
anaplastic lymphoma kinase, rare mutations, STRN-ALK fusion, case report
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