STRN‑ALK fusion, rare variant of ALK gene – case report


MUDr. Jaromír Roubec, Ph.D.; MUDr. Jaroslav Krátký

Nemocnice AGEL Ostrava-Vítkovice Komplexní onkologické centrum, Nový Jičín



In connection with their own case report, the authors discuss the issue of rare mutations in the gene for anaplastic lymphoma kinase (ALK), known mechanisms of increased tumorigenesis of such mutated non-small cell lung cancer tumors and the possibilities of their therapeutic management using tyrosine kinase inhibitors. Literature sources and documented cases of a rare STRN-ALK fusion mutation are presented.


Key words

anaplastic lymphoma kinase, rare mutations, STRN-ALK fusion, case report



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