Gastric neuroendocrine neoplasms

05/2019

MUDr. Michaela Miškovičová

Onkologická klinika 1. LF UK a VFN, Praha

SUMMARY

Gastric neuroendocrine neoplasms are rare lesions consisting of a heterogenous group of neoplasms. The majority of them arise from ECL (enterochromaffin-like) cells - neuroendocrine cells of gastric mucosa, which produce histamin and have the impact on the regulation of gastric secretion. This is why we can call them “ECLomas”. Their incidence is increasing, due to the widespread use of upper digestive endoscopy and the technical refinement of endoscopists. Gastric neuroendocrine neoplasms comprise tumor types of varying pathogenesis, histomorphologic characteristic, biological behavior and prognosis. They can present with clinical symptoms, or can be asymptomatic, carcinoid syndrome is extremely rare. The correct management of patients with gastric neuroendocrine neoplasms can only be proposed when the tumor has been classified by an accurate pathological and clinical evaluation of the patient.

Key words

neuroendocrine neoplasms, ECL cell, histamine, gastric acid, chronic atrophic gastritis, hypergastrinemia