First experience with abemaciclib in real clinical practice – case report


MUDr. Dagmar Brančíková, Ph.D.

Interní hematologická a onkologická klinika LF MU a FN, Brno



We describe the case of a 41-year-old patient with breast cancer, where there was primarily surgical liver dissemination and then bone dissemination. The immunoprofile of the hormone-dependent primary tumor was different from the metastasis, which was triplet negative. The patient was treated systemically with hormone therapy with tamoxifen and a combination of cyclin-dependent kinase inhibitors and letrozole. Cyclin-dependent kinase inhibitors were varied according to the adverse event profile. The best tolerated treatment was the combination of abemaciclib with letrozole. Treatment with the combination with denosumab was effective, we achieved partial remission of lung metastases and stabilization of bone.


Key words

hormone-dependent breast cancer, letrozole, abemaciclib, metastasis immunoprofile



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