EGFR mutations in non‑small cell lung cancer – treatment options


MUDr. Daniel Krejčí; MUDr. Jana Krejčí; doc. MUDr. Norbert Pauk, Ph.D.

Klinika pneumologie 3. LF UK a Nemocnice Na Bulovce, Praha



Worldwide, lung cancer is one of the most common oncological disease. Targeted analysis of the mutation status in non-small cell lung carcinoma detects 10-15 % of patients with a mutated epidermal growth factor receptor gene, whose presence is significant prognostically and therapeutically.1 Diagnosis is based on molecular-genetic methods.2 Depending on the patient's performance status and type of mutation, the patient is indicated for therapy with tyrosine kinase inhibitors, which in this group of patients promise a good response to treatment with a favorable safety profile.13


Key words

epidermal growth factor receptor, tyrosine kinase inhibitor



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