Current status and recommendations for biologically targeted treatment

05/2020

MUDr. Leona Koubková

Pneumologická klinika 2. LF UK a FN v Motole, Praha

SUMMARY

A better understanding of the molecular biology of tumors and the expanding possibilities of their genotyping lead to the strengthening of precise medicine, which allows us personalized treatment. It is mainly genetic changes in the tumor that help us predict the response to molecularly targeted therapy and thus choose the most effective treatment for our patients. The introduction of targeted therapy based on molecular typing into clinical practice has succeeded in significantly prolonging the survival of patients with non-small cell lung cancer, sometimes by several years with a very good quality of life.

Key words

non-small cell lung cancer, targeted treatment, EGFR, ALK, ROS1, BRAF, NTRK, MET