Autoimmune cytopenia in patients with chronic lymphocytic leukemia
05/2020
MUDr. Jana Zuchnická1; MUDr. Jana Mihályová1; MUDr. Jaromír Gumulec1,2; prof. MUDr. Roman Hájek, CSc.1,2
1 Klinika hematoonkologie FN, Ostrava
2 Lékařská fakulta OU, Ostrava
SUMMARY
Chronic lymphocytic leukemia is accompanied by dysfunction of the immune system. Immune dysbalances are manifested, among other things, in an increased incidence of autoimmune cytopenias. In order to choose the right therapeutic procedure, it is important to differentially diagnose other causes of anemia, thrombocytopenia or granulocytopenia. Corticoids, intravenous immunoglobulins, rituximab, or other immunosuppressants are mainly used in therapy. Inadequate response to therapy is an indication to initiate treatment for chronic lymphocytic leukemia.
Key words
chronic lymphocytic leukemia, autoimmune cytopenia, autoimmune hemolytic anemia, immune thrombocytopenia, autoimmune granulocytopenia
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