Atypical manifestation of non‑small cell lung carcinoma – case report


MUDr. Tomáš Hanslík1; MUDr. Zdeněk Chovanec, Ph.D.1; MUDr. Alena Berková, Ph.D.1; MUDr. Stanislav Špelda2; MUDr. Michal Benej, Ph.D.1; MUDr. Adam Peštál, Ph.D.1; MUDr. Vadim Prudius, Ph.D.1; prof. MUDr. Ivan Čapov, CSc.1; MUDr. Vladimír Červeňák3; MUDr. Tetiana Shatokhina4

1 I. chirurgická klinika LF MU a FN u sv. Anny v Brně

2 Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno

3 Klinika zobrazovacích metod LF MU a FN u sv. Anny v Brně

4 I. ústav patologie LF MU a FN u sv. Anny v Brně



The authors acquaint the readers through a case report with a patient in whom non-small cell lung cancer manifested itself in an atypically bulky arching of the chest wall. Initially, it acted clinically and radiologically as chest wall sarcoma, as no tumorous infiltration of the lung parenchyma was evident. There was also a deposit of the right thyroid lobe of uncertain origin. Finally a number of immunohistochemical tests have brought about the resolution and diagnosis. According to genetic examination, the presence of a programmed cell death-ligand 1 (PD-L1) mutation was demonstrated in the cancer, and subsequently immunological therapy was used, which led to a significant regression of the tumor mass of the chest wall.


Key words

non-small cell lung carcinoma, NSCLC, atypical manifestation



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