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4D MR adaptive brachytherapy of uterine cervix carcinoma in FN Hradec Králové
01/2019 MUDr. Igor Sirák, Ph.D.; Petra Sýkorová; Ing. Jakub Grepl; Ing. Petr Paluska; Šárka Kollárová; Iva Dostálová; Ing. Martin Kopeček; Martina Šůnová; Monika Sedláčková; Ing. Linda Kašaová; MUDr. Miroslav Hodek, Ph.D.; MUDr. Milan Vošmik, Ph.D.
Radiotherapy and particulary brachytherapy have been major treatment modalities for cervical cancer for over 100 years. Most of this time the brachytherapy treatment planning was based on radiographs and reference point dosimetry. Due to research of European Society for Radiotherapy and Oncology (GEC-ESTRO) a 3D brachytherapy planning, based on the magnetic resonance imaging with adaptation of the treatment to actual tumor regression in time (4D), has become a standard of care in the last decade. University hospital in Hradec Kralove is the first center in the Czech Republic to implement the adaptive brachytherapy planning of cervical carcinoma based solely on the magnetic resonance imaging for each fraction.
ENTIRE ARTICLE
Radiotherapy and particulary brachytherapy have been major treatment modalities for cervical cancer for over 100 years. Most of this time the brachytherapy treatment planning was based on radiographs and reference point dosimetry. Due to research of European Society for Radiotherapy and Oncology (GEC-ESTRO) a 3D brachytherapy planning, based on the magnetic resonance imaging with adaptation of the treatment to actual tumor regression in time (4D), has become a standard of care in the last decade. University hospital in Hradec Kralove is the first center in the Czech Republic to implement the adaptive brachytherapy planning of cervical carcinoma based solely on the magnetic resonance imaging for each fraction.
Treatment with peroral vinorelbine in 98‑year old patient with locally advanced breast carcinoma – case report
05/2017 MUDr. Igor Sirák
Locally advanced breast carcinoma is generally treated with systemic therapy prior to locoregional surgery and/or radiotherapy. Antracycline and taxane based chemotherapy is the method of choice in the neoadjuvant treatment, with considerable toxicity that make the treatment impossible in elderly and frail patients. On the other hand, peroral vinorelbine is generally well tolerated in older women with metastatic breast carcinoma, on the basis of prospective trials and long-term clinical practice. This is a case report describing excellent effect and tolerance to long-term vinorelbine chemotherapy in very old and frail woman with chemonaive locally advanced breast carcinoma. Long-term treatment with lasting and re-inducible response and good quality of life can be achieved by this accessible and inexpensive approach.
ENTIRE ARTICLE
Locally advanced breast carcinoma is generally treated with systemic therapy prior to locoregional surgery and/or radiotherapy. Antracycline and taxane based chemotherapy is the method of choice in the neoadjuvant treatment, with considerable toxicity that make the treatment impossible in elderly and frail patients. On the other hand, peroral vinorelbine is generally well tolerated in older women with metastatic breast carcinoma, on the basis of prospective trials and long-term clinical practice. This is a case report describing excellent effect and tolerance to long-term vinorelbine chemotherapy in very old and frail woman with chemonaive locally advanced breast carcinoma. Long-term treatment with lasting and re-inducible response and good quality of life can be achieved by this accessible and inexpensive approach.