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Acute promyelocytic leukemia of variant RARα translocation - a case report
02/2019 MUDr. Radka Šimečková
Acute promyelocytic leukemia (APL) is a rare disease. APL is frequently associated with disseminated intravascular coagulation and increased fibrinolysis. The origin and development of the disease is 99 % associated with the reciprocal translocation of the alpha-retinoic acid (RARα) gene from chromosome 17 on chromosome 15 to the region of the gene called the promyelocytic leukemia gene (PML). The result of this translocation is the PML/RARα fusion gene. In less than 1%, the RARα gene fuses with other variant genes than PML. This article presents the case of APL with variant RARα translocation, focused on morphological findings.
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Acute promyelocytic leukemia (APL) is a rare disease. APL is frequently associated with disseminated intravascular coagulation and increased fibrinolysis. The origin and development of the disease is 99 % associated with the reciprocal translocation of the alpha-retinoic acid (RARα) gene from chromosome 17 on chromosome 15 to the region of the gene called the promyelocytic leukemia gene (PML). The result of this translocation is the PML/RARα fusion gene. In less than 1%, the RARα gene fuses with other variant genes than PML. This article presents the case of APL with variant RARα translocation, focused on morphological findings.