Selected articles
Articles for label Šámal Vladimír are displayed.. Show all articles
ARTA treatment of metastatic castration‑resistant prostate cancer – case report
02/2021 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Vladimír Šámal, Ph.D.; MUDr. Jiří Bartoš, MBA
The treatment landscape for metastatic castration-resistant prostate cancer (mCRPC) has rapidly evolved over the past 10 years. The addition chemotherapy (docetaxel, cabazitaxel), androgen receptor targeted agents (ARTA - abiraterone, enzalutamide) and radium 223 has improved outcomes for patients with mCRPC. Abiraterone in our clinical practice is applied most often before the docetaxel-based chemotherapy. We present a case study of patient with mCRPC treated by abirateron (before chemotherapy) for four years.
ENTIRE ARTICLE
The treatment landscape for metastatic castration-resistant prostate cancer (mCRPC) has rapidly evolved over the past 10 years. The addition chemotherapy (docetaxel, cabazitaxel), androgen receptor targeted agents (ARTA - abiraterone, enzalutamide) and radium 223 has improved outcomes for patients with mCRPC. Abiraterone in our clinical practice is applied most often before the docetaxel-based chemotherapy. We present a case study of patient with mCRPC treated by abirateron (before chemotherapy) for four years.
Higher line treatment of metastatic renal cell carcinoma
02/2021 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Vladimír Šámal, Ph.D.; MUDr. Jiří Bartoš, MBA
Targeted therapy and immunotherapy have improved survival outcomes for patients with metastatic renal cell carcinoma. ESMO, NCCN and Czech society for oncology provide some guidelines for the most appropriate first-, secondand third-line treatment. With the growing number of available therapeutic agents and improved survival, the optimal treatment patterns in fourth-line therapy need to be examined. No robust evidence exists to optimize treatment selection in this setting. The fourth-line therapy varies significantly amongst different centers and jurisdictions.
ENTIRE ARTICLE
Targeted therapy and immunotherapy have improved survival outcomes for patients with metastatic renal cell carcinoma. ESMO, NCCN and Czech society for oncology provide some guidelines for the most appropriate first-, secondand third-line treatment. With the growing number of available therapeutic agents and improved survival, the optimal treatment patterns in fourth-line therapy need to be examined. No robust evidence exists to optimize treatment selection in this setting. The fourth-line therapy varies significantly amongst different centers and jurisdictions.
Strategies sequential treatment of metastatic castration‑resistant prostate cancer
02/2020 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Vladimír Šámal, Ph.D.; MUDr. Jiří Bartoš, MBA
Prostate cancer is the most common male malignant neoplasm in men worldwide and second cause of cancer related death. During the last decade, the treatment of metastatic castration resistant prostate cancer has dramatically changed with the approval of new agents as cabazitaxel, enzalutamide, abiraterone and radium 223. These new therapeutic options have provided an overall survival increase from 14-18 months to average of 30-36 months. The problem is the absence of the clearly defined predictive marker. In this review we discussing to choose the optimal treatment sequence of this disease.
ENTIRE ARTICLE
Prostate cancer is the most common male malignant neoplasm in men worldwide and second cause of cancer related death. During the last decade, the treatment of metastatic castration resistant prostate cancer has dramatically changed with the approval of new agents as cabazitaxel, enzalutamide, abiraterone and radium 223. These new therapeutic options have provided an overall survival increase from 14-18 months to average of 30-36 months. The problem is the absence of the clearly defined predictive marker. In this review we discussing to choose the optimal treatment sequence of this disease.
First‑line treatment of metastatic renal cell carcinoma
03/2019 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Jiří Baroš; MUDr. Vladimír Šámal
Renal cell cancer accounts 2-3 % of all cases of malignancy. Sunitinib and Pazopanib have so far been standard in first line treatment of metastatic renal cell cancer. In this review we discuss current first-line treatment options as new tyrosine kinase inhibitor cabozantinib, the new combination of immunotherapy (nivolumab plus ipilimumab), and combination of immunotherapy and tyrosine kinase inhibitor. With the growing therapeutic options, identification of new biomarkers will be crucial for optimizing first-line selection.
ENTIRE ARTICLE
Renal cell cancer accounts 2-3 % of all cases of malignancy. Sunitinib and Pazopanib have so far been standard in first line treatment of metastatic renal cell cancer. In this review we discuss current first-line treatment options as new tyrosine kinase inhibitor cabozantinib, the new combination of immunotherapy (nivolumab plus ipilimumab), and combination of immunotherapy and tyrosine kinase inhibitor. With the growing therapeutic options, identification of new biomarkers will be crucial for optimizing first-line selection.