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Neoadjuvant systemic treatment of HER2 positive breast cancer – case report
04/2019 MUDr. Katarína Petráková, Ph.D.
The primary goal of neoadjuvant systemic therapy in patients with early breast cancer is the down-staging of the disease and achieving operability of the primarily inoperable tumor or achieving less radical surgery. Achieving complete pathological remission affects the long-term prognosis of patients, mainly in triple negative breast cancer and non-luminal HER2 (human epidermal receptor 2, positive for breast epidermal growth factor 2). In the case report we present a case of a patient with locally advanced HER2-positive breast cancer who achieved complete remission by intensive neoadjuvant systemic treatment using dual HER2 receptor blockade, which could significantly reduce subsequent surgical treatment.
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The primary goal of neoadjuvant systemic therapy in patients with early breast cancer is the down-staging of the disease and achieving operability of the primarily inoperable tumor or achieving less radical surgery. Achieving complete pathological remission affects the long-term prognosis of patients, mainly in triple negative breast cancer and non-luminal HER2 (human epidermal receptor 2, positive for breast epidermal growth factor 2). In the case report we present a case of a patient with locally advanced HER2-positive breast cancer who achieved complete remission by intensive neoadjuvant systemic treatment using dual HER2 receptor blockade, which could significantly reduce subsequent surgical treatment.