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Laboratory aspects of human papillomavirus testing
01/2017 Kateřina Sieglová, Hana Vošmiková, Jan Laco, Ivo Šteiner
Human papillomavirus (HPV) has been known as the main etiological factor of cervical carcinoma al ready in 1983. Since then, HPV is recognized in relation with carcinomas of other organs of anogenital tract and also of the head and neck region. Recently, it became obvious that HPV-associated squamous cell carcinomas differ significantly from the HPV-negative ones - in the epidemiology, biological behavior and prognosis. Therefore, HPV testing of tumor tissue becomes clinically important. The reis a number of methods for HPV detection, with varying requirements for the biological material and also for their sensitivity, validity and cost. According to these differences, it is important to select optimal method for HPV detection.
ENTIRE ARTICLE
Human papillomavirus (HPV) has been known as the main etiological factor of cervical carcinoma al ready in 1983. Since then, HPV is recognized in relation with carcinomas of other organs of anogenital tract and also of the head and neck region. Recently, it became obvious that HPV-associated squamous cell carcinomas differ significantly from the HPV-negative ones - in the epidemiology, biological behavior and prognosis. Therefore, HPV testing of tumor tissue becomes clinically important. The reis a number of methods for HPV detection, with varying requirements for the biological material and also for their sensitivity, validity and cost. According to these differences, it is important to select optimal method for HPV detection.
Human papillomaviruses and their role in the etiopathogenesis of malignant tumors
01/2017 Jan Laco
Human papillomaviruses, most commonly transmitted by sexual intercourse, are important pathogens, which significantly contribute to the formation of benign mucocutaneous lesions, e.g., squamous cell papillomas, condylomas, and warts, and of malignant tumors of anogenital and head and neck areas. They are the most important risk factors for cervical, vaginal and anal carcinomas, and they also play a role in the development of a subset of vulvar and penile carcinomas. In head and neck area, the are strongly associated with oropharyngeal carcinoma, mostly affecting palatine tonsils and root of tongue, and with a subset of sinonasal carcinomas.
ENTIRE ARTICLE
Human papillomaviruses, most commonly transmitted by sexual intercourse, are important pathogens, which significantly contribute to the formation of benign mucocutaneous lesions, e.g., squamous cell papillomas, condylomas, and warts, and of malignant tumors of anogenital and head and neck areas. They are the most important risk factors for cervical, vaginal and anal carcinomas, and they also play a role in the development of a subset of vulvar and penile carcinomas. In head and neck area, the are strongly associated with oropharyngeal carcinoma, mostly affecting palatine tonsils and root of tongue, and with a subset of sinonasal carcinomas.