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Advanced hepatocellular carcinoma and successfully targeted the first‑line treatment with atezolizumab and bevacizumab according to IMbrave150 trial
03/2021 Prof. MUDr. Samuel Vokurka, Ph.D.
Hepatocellular carcinoma is a prognostically unfavorable malignancy with very limited possibilities to influence its course, especially in advanced stages of the disease. Treatment with atezolizumab and bevacizumab in the IMbrave150 study showed a significant prolongation of median progression and overall survival of 19,2 versus 13,4 months in sorafenib group of patients (HR 0,66; p = 0,0009). This has been the longest survival observed in the first-line phase III study in advanced hepatocellular carcinoma, so far.
ENTIRE ARTICLE
Hepatocellular carcinoma is a prognostically unfavorable malignancy with very limited possibilities to influence its course, especially in advanced stages of the disease. Treatment with atezolizumab and bevacizumab in the IMbrave150 study showed a significant prolongation of median progression and overall survival of 19,2 versus 13,4 months in sorafenib group of patients (HR 0,66; p = 0,0009). This has been the longest survival observed in the first-line phase III study in advanced hepatocellular carcinoma, so far.
Denosumab – an important part of the treatment of patients with skeletal metastatic disease
06/2020 Prof. MUDr. Samuel Vokurka, Ph.D.
Denosumab, 120 mg inj. s.c., significantly contributes to delaying the development of skeletal related events (pathological fracture, spinal cord compression, a condition requiring radiotherapy or surgery to bone) and worsening pain in patients with skeletal metastatic disease. Initial dental care with prophylactic stomatology interventions and proper supplementation of calcium and vitamin D are an integral part and condition for successful treatment with denosumab.
ENTIRE ARTICLE
Denosumab, 120 mg inj. s.c., significantly contributes to delaying the development of skeletal related events (pathological fracture, spinal cord compression, a condition requiring radiotherapy or surgery to bone) and worsening pain in patients with skeletal metastatic disease. Initial dental care with prophylactic stomatology interventions and proper supplementation of calcium and vitamin D are an integral part and condition for successful treatment with denosumab.
The importance of supportive care in onkology
05/2018 Doc. MUDr. Samuel Vokurka, Ph.D.
The role of supportive and nursing care is crucial in oncology. It prevents and solves the difficulties and complications caused by cancer and oncological treatment. It has a proven effect on improving the quality of life and oncological treatment outcomes. It addresses both physical and psychosocial and educational issues. Multidisciplinary collaboration among specialists, nurses and patients is essential.
ENTIRE ARTICLE
The role of supportive and nursing care is crucial in oncology. It prevents and solves the difficulties and complications caused by cancer and oncological treatment. It has a proven effect on improving the quality of life and oncological treatment outcomes. It addresses both physical and psychosocial and educational issues. Multidisciplinary collaboration among specialists, nurses and patients is essential.