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Articles for label Holánek Miloš are displayed.. Show all articles
Current treatment options for early HER2-positive breast cancer
04/2020 MUDr. Miloš Holánek
Anti-HER2 therapy has long been an integral part of the treatment of patients with HER2-positive breast cancer, which has significantly improved treatment outcomes and disease prognosis. However, despite effective therapy, some patients still relapse. Therefore, other possibilities are being sought to further improve the already very effective therapy.
ENTIRE ARTICLE
Anti-HER2 therapy has long been an integral part of the treatment of patients with HER2-positive breast cancer, which has significantly improved treatment outcomes and disease prognosis. However, despite effective therapy, some patients still relapse. Therefore, other possibilities are being sought to further improve the already very effective therapy.
Palbociclib in the context of other CDK4/6 inhibitors
04/2017 MUDr. Miloš Holánek
Hormonal treatment in patients with disseminated, hormonal dependent breast cancer is a clearly preferred treatment alternative. It should be considered in all patients, regardless of the extent and location of the disease. Only in the case of a rapidly progressive and aggressive disease with signs of a visceral crisis is chemotherapy an option, because the onset of chemotherapy is faster than the onset of the hormone treatment. Currently, the possibilities of hormonal therapy of advanced breast cancer are changing - due to the combination of hormone therapy with cyclin-dependent kinase 4/6 inhibitors (CDK4/6), there has been a marked improvement in the effectiveness of therapy. Improvement in treatment occurred in all subgroups of patients who received CDK4/6 inhibitors. Until now, no predictor has been identified. Palbociclib, ribociclib, and abemaciclib were evaluated in clinical trials. This article summarizes the effectiveness and tolerance of these preparations.
ENTIRE ARTICLE
Hormonal treatment in patients with disseminated, hormonal dependent breast cancer is a clearly preferred treatment alternative. It should be considered in all patients, regardless of the extent and location of the disease. Only in the case of a rapidly progressive and aggressive disease with signs of a visceral crisis is chemotherapy an option, because the onset of chemotherapy is faster than the onset of the hormone treatment. Currently, the possibilities of hormonal therapy of advanced breast cancer are changing - due to the combination of hormone therapy with cyclin-dependent kinase 4/6 inhibitors (CDK4/6), there has been a marked improvement in the effectiveness of therapy. Improvement in treatment occurred in all subgroups of patients who received CDK4/6 inhibitors. Until now, no predictor has been identified. Palbociclib, ribociclib, and abemaciclib were evaluated in clinical trials. This article summarizes the effectiveness and tolerance of these preparations.