Selected articles
Articles for label Fínek Jindřich are displayed.. Show all articles
Immunotherapy and radiotherapy in locally advanced (metastatic) non‑small cell lung cancer
01/2020 Special Edition - MUDr. Gabriela Krákorová, Ph.D.; MUDr. Hana Steinbergerová; prof. MUDr. Miloš Pešek, CSc.; prof. MUDr. Jindřich Fínek, Ph.D., MHA; MUDr. Tomáš Svoboda, Ph.D.
Non-small cell lung cancer even today is a big socioeconomic problem for beeing diagnosed in an advanced or metastatic stage in majority of tumors when our treatment methods available at that time unfortunately are not associated with satisfactory results except few patients with tumors carrying specific mutations. Radiochemotherapy remains the basic standard regimen while adding induction or maintenance cytotoxic treatment did not count for any other benefit. However, modern immunotherapy by PD-1 and PD-L1 inhibitors brings a huge hope today. Mainly it's combination with radiation therapy sensibilizing to a better immunotherapy effect could become a standard part in majority of treatment guidelines. In this context, hypofractionated radiation regimens with limited target volumes seem to be preferred to normofractionation and larger fields. The role of abscopal effect remains still uncertain.
ENTIRE ARTICLE
Non-small cell lung cancer even today is a big socioeconomic problem for beeing diagnosed in an advanced or metastatic stage in majority of tumors when our treatment methods available at that time unfortunately are not associated with satisfactory results except few patients with tumors carrying specific mutations. Radiochemotherapy remains the basic standard regimen while adding induction or maintenance cytotoxic treatment did not count for any other benefit. However, modern immunotherapy by PD-1 and PD-L1 inhibitors brings a huge hope today. Mainly it's combination with radiation therapy sensibilizing to a better immunotherapy effect could become a standard part in majority of treatment guidelines. In this context, hypofractionated radiation regimens with limited target volumes seem to be preferred to normofractionation and larger fields. The role of abscopal effect remains still uncertain.
Pembrolizumab in our country and over the ocean
05/2019 Prof. MUDr. Jindřich Fínek, Ph.D., MHA
Pembrolizumab is a humanized monoclonal antibody against programmed cell death 1 receptors (PD-1) (an IgG4/K isotype with a stabilizing sequence change in the Fc region) produced by recombinant DNA technology in Chinese hamster ovary cells.
ENTIRE ARTICLE
Pembrolizumab is a humanized monoclonal antibody against programmed cell death 1 receptors (PD-1) (an IgG4/K isotype with a stabilizing sequence change in the Fc region) produced by recombinant DNA technology in Chinese hamster ovary cells.
New sequences in higher lines of treatment of clear cell carcinoma of the kidney
03/2018 Prof. MUDr. Jindřich Fínek, Ph.D., MHA
Two new molecules, nivolumab (anti-PD-1) and cabozantinib (a multikinase inhibitor of the VEGF, AXL and MET pathway), are coming into the treatment of metastatic clear cell carcinoma of the kidneys. In the second treatment line, both offer an identical survival extension of five months compared to everolimus. Cabozantinib appears to be more appropriate in patients with bone metastases and when rapid onset of action is required. In contrast, nivolumab has an advantage in patients with high tumor burden.
ENTIRE ARTICLE
Two new molecules, nivolumab (anti-PD-1) and cabozantinib (a multikinase inhibitor of the VEGF, AXL and MET pathway), are coming into the treatment of metastatic clear cell carcinoma of the kidneys. In the second treatment line, both offer an identical survival extension of five months compared to everolimus. Cabozantinib appears to be more appropriate in patients with bone metastases and when rapid onset of action is required. In contrast, nivolumab has an advantage in patients with high tumor burden.
Bevacizumab in the treatment of solid tumors
05/2017 Prof. MUDr. Jindřich Fínek, Ph.D., MHA
Bevacizumab is a universal anti-VEGF drug effective in numerous solid tumors in combination with chemotherapy.
ENTIRE ARTICLE
Bevacizumab is a universal anti-VEGF drug effective in numerous solid tumors in combination with chemotherapy.