Selected articles
Articles for label Doležel Martin are displayed.. Show all articles
Monitoring of patients with prostate cancer after external radiotherapy
02/2021 MUDr. Petra Holubová, Ph.D.; doc. MUDr. Martin Doležel, Ph.D.; MUDr. Igor Hartmann, Ph.D.
Serial evaluation of serum prostate-specific antigen is the mainstay of surveillance testing in men who have undergone definitive radiotherapy for localized prostate cancer. Based on the National Comprehensive Cancer Network guidelines serum prostate-specific antigen should be monitored every 6 to 12 months for the first five years and annually thereafter. There were created several nomograms to estimate a patienťs probability of long-term cure after radical local treatment using pathologic stage as a surrogate end point. Positron emission tomography using choline 18F-ftuciclovine and 68Ga-labelled prostate-specific membrane antigen are an emerging radiological techniques developed to improve the characterization of relapsed prostate cancer. We can use several accepted toxicity grading scales for quantification of degree of damage of organs at risk (RTOG, FC-LENT SOMA, Common Terminology Criteria for Adverse Events).
ENTIRE ARTICLE
Serial evaluation of serum prostate-specific antigen is the mainstay of surveillance testing in men who have undergone definitive radiotherapy for localized prostate cancer. Based on the National Comprehensive Cancer Network guidelines serum prostate-specific antigen should be monitored every 6 to 12 months for the first five years and annually thereafter. There were created several nomograms to estimate a patienťs probability of long-term cure after radical local treatment using pathologic stage as a surrogate end point. Positron emission tomography using choline 18F-ftuciclovine and 68Ga-labelled prostate-specific membrane antigen are an emerging radiological techniques developed to improve the characterization of relapsed prostate cancer. We can use several accepted toxicity grading scales for quantification of degree of damage of organs at risk (RTOG, FC-LENT SOMA, Common Terminology Criteria for Adverse Events).
Immunomodulatory effect of radiotherapy
Supplementum 01/2019 Imunoterapie
Doc. MUDr. Martin Doležel, Ph.D.
The recent achievements of both preclinical and clinical immunooncological research have led to an increased interest in the immunomodulatory effect of radiotherapy and the associated necessity of assessing the effect of the combination of immunotherapy and ionizing radiation. An example is the PACIFIC study, which demonstrated that the combination of chemoradiotherapy and the durvalumab inhibitor checkpoint significantly improved the overall survival of non-small cell lung cancer patients at a median of 25.2 months. The enormous amount of ongoing studies is a great promise of new treatment options in the near future.
ENTIRE ARTICLE
Doc. MUDr. Martin Doležel, Ph.D.
The recent achievements of both preclinical and clinical immunooncological research have led to an increased interest in the immunomodulatory effect of radiotherapy and the associated necessity of assessing the effect of the combination of immunotherapy and ionizing radiation. An example is the PACIFIC study, which demonstrated that the combination of chemoradiotherapy and the durvalumab inhibitor checkpoint significantly improved the overall survival of non-small cell lung cancer patients at a median of 25.2 months. The enormous amount of ongoing studies is a great promise of new treatment options in the near future.