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Osimertinib in adjuvant treatment EGFR+ non‑small cell lung cancer – ADAURA trial
05/2021 MUDr. Ondřej Bílek
Approximately one-quarter of patients with non-small cell lung cancer are diagnosed with early or locally advanced stage of the disease suitable for surgery. There is a high risk of disease recurrence after adjuvant chemotherapy. The ADAURA trial demonstrated a significant benefit of adjuvant treatment with osimertinib in patients with non-small cell lung cancer with evidence of aberration of EGFR del19 or L858R in exon 21.
ENTIRE ARTICLE
Approximately one-quarter of patients with non-small cell lung cancer are diagnosed with early or locally advanced stage of the disease suitable for surgery. There is a high risk of disease recurrence after adjuvant chemotherapy. The ADAURA trial demonstrated a significant benefit of adjuvant treatment with osimertinib in patients with non-small cell lung cancer with evidence of aberration of EGFR del19 or L858R in exon 21.
Consolidation immunotherapy with durvalumab in the treatment of locally advanced non‑small cell lung cancer
01/2021 MUDr. Ondřej Bílek
In about a quarter of cases, non-small cell lung cancer (NSCLC) is diagnosed at the stage of locally advanced disease. The standard treatment for these patients is concomitant chemotherapy and radiotherapy. Currently, immunotherapy is an integral part of the treatment of the NSCLC treatment algorithm, especially anti-PD-1 and anti-PD-L1 check-point inhibitors. Data from the PACIFIC study demonstrated a significant benefit of consolidating immunotherapy with the anti-PD-L1 monoclonal antibody durvalumab after cessation of radiotherapy, including prolongation of overall survival. Durvalumab is currently the reference molecule in this indication. Tolerance and safety profile are favorable, early diagnosis and treatment of immune-related adverse events is necessary.
ENTIRE ARTICLE
In about a quarter of cases, non-small cell lung cancer (NSCLC) is diagnosed at the stage of locally advanced disease. The standard treatment for these patients is concomitant chemotherapy and radiotherapy. Currently, immunotherapy is an integral part of the treatment of the NSCLC treatment algorithm, especially anti-PD-1 and anti-PD-L1 check-point inhibitors. Data from the PACIFIC study demonstrated a significant benefit of consolidating immunotherapy with the anti-PD-L1 monoclonal antibody durvalumab after cessation of radiotherapy, including prolongation of overall survival. Durvalumab is currently the reference molecule in this indication. Tolerance and safety profile are favorable, early diagnosis and treatment of immune-related adverse events is necessary.
Durvalumab in the treatment of non‑small cell lung cancer
01/2020 Special Edition - MUDr. Ondřej Bílek
Lung cancer represents the leading cause of cancer death worldwide. Most of the patients are diagnosed with advanced disease. Targeting immune-checkpoint inhibitors represents a standard option for advanced non-small cell lung cancer. The aim of this review is to summarize and discuss the clinical evidence for the use of durvalumab in advanced NSCLC.
ENTIRE ARTICLE
Lung cancer represents the leading cause of cancer death worldwide. Most of the patients are diagnosed with advanced disease. Targeting immune-checkpoint inhibitors represents a standard option for advanced non-small cell lung cancer. The aim of this review is to summarize and discuss the clinical evidence for the use of durvalumab in advanced NSCLC.