Selected articles
Articles for label Batko Stanislav are displayed.. Show all articles
Anti‑EGFR treatment of colorectal cancer
03/2021 MUDr. Stanislav Batko
Treatment of metastatic colorectal cancer is based on the combination of chemotherapy and targeted therapy, in which anti-EGFR monoclonal antibodies cetuximab and panitumumab play a very important role in RAS + BRAF wild-type subgroup of patients. They have showed prolonged progression-free survival throughout all lines, with prolongation of overall survival demonstrated in first- and third-line studies. The most significant benefit in overall survival can be observed, when they are used in chemonaive metastatic colorectal cancer. In this setting anti-EGFR (epidermal growth factor receptor) therapies pro- vide deep and durable response. This effect of tumor mass reduction simultaneously allows a significant proportion of patients to achieve conversion and secondary resection of metastases associated with longer survival and potential for curability. In addition to the most commonly used doublets FOLFOX and FOLFIRI, panitumumab can be used in combination with 5-fluorouracil and leucovorin in elderly patients while maintaining its efficacy. At the same time, there is increasing experience with the use of anti-EGFR therapies in combination with the FOLFOXIRI triplet, demonstrating high potential to achieve resectability. The indication criteria have been newly expanded to include BRAF V600E mutated pre- treated metastatic colorectal cancer, where the combination of cetuximab with encorafenib resulted in a significant prolongation of overall survival.
ENTIRE ARTICLE
Treatment of metastatic colorectal cancer is based on the combination of chemotherapy and targeted therapy, in which anti-EGFR monoclonal antibodies cetuximab and panitumumab play a very important role in RAS + BRAF wild-type subgroup of patients. They have showed prolonged progression-free survival throughout all lines, with prolongation of overall survival demonstrated in first- and third-line studies. The most significant benefit in overall survival can be observed, when they are used in chemonaive metastatic colorectal cancer. In this setting anti-EGFR (epidermal growth factor receptor) therapies pro- vide deep and durable response. This effect of tumor mass reduction simultaneously allows a significant proportion of patients to achieve conversion and secondary resection of metastases associated with longer survival and potential for curability. In addition to the most commonly used doublets FOLFOX and FOLFIRI, panitumumab can be used in combination with 5-fluorouracil and leucovorin in elderly patients while maintaining its efficacy. At the same time, there is increasing experience with the use of anti-EGFR therapies in combination with the FOLFOXIRI triplet, demonstrating high potential to achieve resectability. The indication criteria have been newly expanded to include BRAF V600E mutated pre- treated metastatic colorectal cancer, where the combination of cetuximab with encorafenib resulted in a significant prolongation of overall survival.
Metastatic colorectal cancer – case report
04/2020 MUDr. Stanislav Batko
Metastatic colorectal cancer is still a challenge for physicians. Various modalities are used in its treatment, including chemotherapy, targeted treatment and local methods of intervention, including surgical resection, radiofrequency ablation, radiotherapy, chemoand radioembolization. There are relatively loose recommendations for systemic treatment, the involvement of other treatment modalities is defined much more freely, as well as applied in practice. A proactive approach combining the maximum use of systemic treatment, together with the agile application of local methods, can lead to a significant benefit in the overall survival of patients through generally available methods.
ENTIRE ARTICLE
Metastatic colorectal cancer is still a challenge for physicians. Various modalities are used in its treatment, including chemotherapy, targeted treatment and local methods of intervention, including surgical resection, radiofrequency ablation, radiotherapy, chemoand radioembolization. There are relatively loose recommendations for systemic treatment, the involvement of other treatment modalities is defined much more freely, as well as applied in practice. A proactive approach combining the maximum use of systemic treatment, together with the agile application of local methods, can lead to a significant benefit in the overall survival of patients through generally available methods.
Panitumumab in the treatment of colorectal carcinoma
03/2020 MUDr. Stanislav Batko
This article reviews the efficacy panitumumab (Vectibix) in the treatment of metastatic colorectal carcinoma. Fist study published was PRIME in which panitumumab plus FOLFOX compared to chemotherapy alone prolonged overall survival in patients with non-resectable metastatic colorectal cancer (mCRC), furthermore it showed trend towards higher resection rate in patients with liver limited disease (LLD). The PEAK trial was comparing panitumumab and bevacizumab with chemotherapy backbone. Both overall survival and progression-free survival favored panitumumab compared to bevacizumab. PLANET trial was exploring potential of panitumumab to enhance overall response rate and allow for more curative resections in LLD population of mCRC patients. PLANET trial provided evidence high resectability and long overall survival. VOLFI trial represents a reasoned step in searching for more potent combination therapy. In randomized manner it compared FOLFOXIRI alone to FOLFOXIRI plus panitumumab. This study met its primary point, which was ORR, furthermore it showed greatly increased resectability in panitumumab arm and suggested better overall survival. Panitumumab plus FOLFOXIRI pose viable and efficient option for patients with mCRC, where deep tumor response could open way to surgical resection. VALENTINO study shed light on different maintenance strategies in 1st line mCRC after induction FOLFOX + panitumumab. Fluorouracil + leucovorin + panitumumab yielded better results in terms of 10-month PFS compared to panitumumab monotherapy.
ENTIRE ARTICLE
This article reviews the efficacy panitumumab (Vectibix) in the treatment of metastatic colorectal carcinoma. Fist study published was PRIME in which panitumumab plus FOLFOX compared to chemotherapy alone prolonged overall survival in patients with non-resectable metastatic colorectal cancer (mCRC), furthermore it showed trend towards higher resection rate in patients with liver limited disease (LLD). The PEAK trial was comparing panitumumab and bevacizumab with chemotherapy backbone. Both overall survival and progression-free survival favored panitumumab compared to bevacizumab. PLANET trial was exploring potential of panitumumab to enhance overall response rate and allow for more curative resections in LLD population of mCRC patients. PLANET trial provided evidence high resectability and long overall survival. VOLFI trial represents a reasoned step in searching for more potent combination therapy. In randomized manner it compared FOLFOXIRI alone to FOLFOXIRI plus panitumumab. This study met its primary point, which was ORR, furthermore it showed greatly increased resectability in panitumumab arm and suggested better overall survival. Panitumumab plus FOLFOXIRI pose viable and efficient option for patients with mCRC, where deep tumor response could open way to surgical resection. VALENTINO study shed light on different maintenance strategies in 1st line mCRC after induction FOLFOX + panitumumab. Fluorouracil + leucovorin + panitumumab yielded better results in terms of 10-month PFS compared to panitumumab monotherapy.
Panitumumab as first‑line treatment of colorectal cancer
04/2019 MUDr. Stanislav Batko
This article reviews the efficacy panitumumab in the 1st line systemic treatment of metastatic colorectal carcinoma (mCRC). First study published was PRIME in which panitumumab plus FOLFOX compared to chemotherapy alone prolonged overall survival in patients with nonresectable mCRC, furthermore it showed trend towards higher resection rate in patients with liver limited disease. The PEAK trial was comparing panitumumab and bevacizumab with chemotherapy backbone. Both overall survival and progression-free survival favored panitumumab compared to bevacizumab. PLANET trial was exploring potential of panitumumab to enhance overall response rate and allow for more curative resections in LLD population of mCRC patients. PLANET trial provided evidence high resectability and long overall survival. VOLFI trial represents a reasoned step in searching for more potent combination therapy. In randomized manner it compared FOLFOXIRI alone to FOLFOXIRI plus panitumumab. This study met its primary point, which was objective response rate, furthermore it showed greatly increased resectability in panitumumab arm and suggested better overall survival. Panitumumab plus FOLFOXIRI pose viable and efficient option for patients with mCRC, where deep tumor response could open way to surgical resection.
ENTIRE ARTICLE
This article reviews the efficacy panitumumab in the 1st line systemic treatment of metastatic colorectal carcinoma (mCRC). First study published was PRIME in which panitumumab plus FOLFOX compared to chemotherapy alone prolonged overall survival in patients with nonresectable mCRC, furthermore it showed trend towards higher resection rate in patients with liver limited disease. The PEAK trial was comparing panitumumab and bevacizumab with chemotherapy backbone. Both overall survival and progression-free survival favored panitumumab compared to bevacizumab. PLANET trial was exploring potential of panitumumab to enhance overall response rate and allow for more curative resections in LLD population of mCRC patients. PLANET trial provided evidence high resectability and long overall survival. VOLFI trial represents a reasoned step in searching for more potent combination therapy. In randomized manner it compared FOLFOXIRI alone to FOLFOXIRI plus panitumumab. This study met its primary point, which was objective response rate, furthermore it showed greatly increased resectability in panitumumab arm and suggested better overall survival. Panitumumab plus FOLFOXIRI pose viable and efficient option for patients with mCRC, where deep tumor response could open way to surgical resection.