Selected articles
Articles for label Bartoš Jiří are displayed.. Show all articles
ARTA treatment of metastatic castration‑resistant prostate cancer – case report
02/2021 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Vladimír Šámal, Ph.D.; MUDr. Jiří Bartoš, MBA
The treatment landscape for metastatic castration-resistant prostate cancer (mCRPC) has rapidly evolved over the past 10 years. The addition chemotherapy (docetaxel, cabazitaxel), androgen receptor targeted agents (ARTA - abiraterone, enzalutamide) and radium 223 has improved outcomes for patients with mCRPC. Abiraterone in our clinical practice is applied most often before the docetaxel-based chemotherapy. We present a case study of patient with mCRPC treated by abirateron (before chemotherapy) for four years.
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The treatment landscape for metastatic castration-resistant prostate cancer (mCRPC) has rapidly evolved over the past 10 years. The addition chemotherapy (docetaxel, cabazitaxel), androgen receptor targeted agents (ARTA - abiraterone, enzalutamide) and radium 223 has improved outcomes for patients with mCRPC. Abiraterone in our clinical practice is applied most often before the docetaxel-based chemotherapy. We present a case study of patient with mCRPC treated by abirateron (before chemotherapy) for four years.
Higher line treatment of metastatic renal cell carcinoma
02/2021 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Vladimír Šámal, Ph.D.; MUDr. Jiří Bartoš, MBA
Targeted therapy and immunotherapy have improved survival outcomes for patients with metastatic renal cell carcinoma. ESMO, NCCN and Czech society for oncology provide some guidelines for the most appropriate first-, secondand third-line treatment. With the growing number of available therapeutic agents and improved survival, the optimal treatment patterns in fourth-line therapy need to be examined. No robust evidence exists to optimize treatment selection in this setting. The fourth-line therapy varies significantly amongst different centers and jurisdictions.
ENTIRE ARTICLE
Targeted therapy and immunotherapy have improved survival outcomes for patients with metastatic renal cell carcinoma. ESMO, NCCN and Czech society for oncology provide some guidelines for the most appropriate first-, secondand third-line treatment. With the growing number of available therapeutic agents and improved survival, the optimal treatment patterns in fourth-line therapy need to be examined. No robust evidence exists to optimize treatment selection in this setting. The fourth-line therapy varies significantly amongst different centers and jurisdictions.
New drugs in oncology
01/2021 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Jiří Bartoš, MBA
The systemic treatment of malignant tumors has undergone significant changes in recent years. In addition to the hormonal treatment and chemotherapy, we have new therapeutic approaches as immunotherapy or targeted treatment. Many new drugs are added in the treatment of malignant tumor every year. The treatment guidelines have been updated and changed. The aim of this review is to provide summary of new drugs in treatment of solid tumors. This article presents an overview of the two groups of agents as tyrosine kinase inhibitors and monoclonal antibodies, due to extensive issues.
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The systemic treatment of malignant tumors has undergone significant changes in recent years. In addition to the hormonal treatment and chemotherapy, we have new therapeutic approaches as immunotherapy or targeted treatment. Many new drugs are added in the treatment of malignant tumor every year. The treatment guidelines have been updated and changed. The aim of this review is to provide summary of new drugs in treatment of solid tumors. This article presents an overview of the two groups of agents as tyrosine kinase inhibitors and monoclonal antibodies, due to extensive issues.
Strategies sequential treatment of metastatic castration‑resistant prostate cancer
02/2020 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Vladimír Šámal, Ph.D.; MUDr. Jiří Bartoš, MBA
Prostate cancer is the most common male malignant neoplasm in men worldwide and second cause of cancer related death. During the last decade, the treatment of metastatic castration resistant prostate cancer has dramatically changed with the approval of new agents as cabazitaxel, enzalutamide, abiraterone and radium 223. These new therapeutic options have provided an overall survival increase from 14-18 months to average of 30-36 months. The problem is the absence of the clearly defined predictive marker. In this review we discussing to choose the optimal treatment sequence of this disease.
ENTIRE ARTICLE
Prostate cancer is the most common male malignant neoplasm in men worldwide and second cause of cancer related death. During the last decade, the treatment of metastatic castration resistant prostate cancer has dramatically changed with the approval of new agents as cabazitaxel, enzalutamide, abiraterone and radium 223. These new therapeutic options have provided an overall survival increase from 14-18 months to average of 30-36 months. The problem is the absence of the clearly defined predictive marker. In this review we discussing to choose the optimal treatment sequence of this disease.
Influence of neoadjuvant chemoradiotherapy on PD‑L1 expression change in rectal cancer patients
03/2019 MUDr. Igor Richter, Ph.D.; doc. MUDr. Josef Dvořák, Ph.D.; MUDr. Jiří Bartoš; doc. MUDr. Tomáš Jirásek, Ph.D.
The neoadjuvant chemoradiotherapy with following total mesorectal excision is a current standard of the treatment of locally advanced rectal adenocarcinoma. In addition to traditional prognostic factors (as clinical stage, surgery radicality, etc.), new biomarkers are also being sought with the aim to optimize the treatment of this malignancy. One of these biomarkers is detection of PD-L1 on the tumor cell surface. The aim of this paper is to determinate the prognostic influence of PD-L1 expression changes in patients with locally advanced rectal cancer treated by neoadjuvant chemoradiotherapy. The combination of PD-1/PD-L1 inhibitors has not gained an acceptance as a new standard of treatment of these malignancies.
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The neoadjuvant chemoradiotherapy with following total mesorectal excision is a current standard of the treatment of locally advanced rectal adenocarcinoma. In addition to traditional prognostic factors (as clinical stage, surgery radicality, etc.), new biomarkers are also being sought with the aim to optimize the treatment of this malignancy. One of these biomarkers is detection of PD-L1 on the tumor cell surface. The aim of this paper is to determinate the prognostic influence of PD-L1 expression changes in patients with locally advanced rectal cancer treated by neoadjuvant chemoradiotherapy. The combination of PD-1/PD-L1 inhibitors has not gained an acceptance as a new standard of treatment of these malignancies.
The position of bevacizumab in the treatment of colorectal cancer
06/2018 MUDr. Igor Richter, Ph.D., doc. MUDr. Josef Dvořák, Ph.D., MUDr. Jiří Bartoš, MBA
Metastatic colorectal cancer is one of the day-to-day diagnoses of oncology centers. In addition to chemotherapy, we also have the opportunity to receive targeted treatment. Bevacizumab is a monoclonal antibody against vascular endothelial factor and we have more than ten years of experience with it. The review article evaluates the current status of bevacizumab in the treatment of metastatic colorectal cancer, where its position in the treatment algorithm of the disease has recently been clarified without a clear predictive factor. Finally, there is a case report of the patient who responds well to chemotherapy in combination with bevacizumab in the first line, despite left-hand localization and the non-mutated RAS gene.
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Metastatic colorectal cancer is one of the day-to-day diagnoses of oncology centers. In addition to chemotherapy, we also have the opportunity to receive targeted treatment. Bevacizumab is a monoclonal antibody against vascular endothelial factor and we have more than ten years of experience with it. The review article evaluates the current status of bevacizumab in the treatment of metastatic colorectal cancer, where its position in the treatment algorithm of the disease has recently been clarified without a clear predictive factor. Finally, there is a case report of the patient who responds well to chemotherapy in combination with bevacizumab in the first line, despite left-hand localization and the non-mutated RAS gene.
Palliative care applied together with oncology treatment in patients with advanced tumors
06/2017 MUDr. Marek Sochor, MUDr. Jiří Bartoš
Patients with advanced cancer, with limited prognosis, are the most demanding group of oncological patients. In that patients anticancer therapy isn't applied with curative intent, it is oriented to prolong life and to make better quality of life. Patients suffer from many physical symptoms, are suspended to psychic distress and have almost complicated social situation. These all factors worsen quality of life, complicate anticancer treatment and shorten life. In the last ten years grows knowledge about significance of early application of multimodality palliative care initiated in time of diagnosis of cancer and realized parallel to anticancer treatment. This concept was confirmed in many randomized trials. In a next future of scientific investigation and real clinical practice we have to figure out who will provide palliative care, which modalities are the most effective and which models of care between palliative care specialists and oncologist are the most suitable for patients. Review article documents our current knowledge about early palliative care in oncology.
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Patients with advanced cancer, with limited prognosis, are the most demanding group of oncological patients. In that patients anticancer therapy isn't applied with curative intent, it is oriented to prolong life and to make better quality of life. Patients suffer from many physical symptoms, are suspended to psychic distress and have almost complicated social situation. These all factors worsen quality of life, complicate anticancer treatment and shorten life. In the last ten years grows knowledge about significance of early application of multimodality palliative care initiated in time of diagnosis of cancer and realized parallel to anticancer treatment. This concept was confirmed in many randomized trials. In a next future of scientific investigation and real clinical practice we have to figure out who will provide palliative care, which modalities are the most effective and which models of care between palliative care specialists and oncologist are the most suitable for patients. Review article documents our current knowledge about early palliative care in oncology.
Enzalutamide in treatment in patients with metastatic castration‑resistant prostate cancer after previous chemotherapy
03/2017 MUDr. Igor Richter, Ph.D., doc. MUDr. Josef Dvořák, Ph.D., MUDr. Věra Hejzlarová, MUDr. Jiří Bartoš, MBA
Introduction: The aim of this retrospective study is demonstrated efficacy and tolerance of enzalutamide therapy in real clinical practice in 33 patients with metastatic castration-resistant prostate cancer (mCRPC) who had previous chemotherapy.
Patients and methods: Between November 2014 and June 2016 we treated with enzalutamide a total of 33 patients with metastatic castrate resistant prostate cancer. The all patients were previous treated by one or two lines of chemotherapy. The enzalutamide was administered by standard dose 160 mg daily.
Results: One patient had cerebral hemorrhage grade IV. In other patients the non-hematological toxicity evaluation did not achieve the grade III or IV. Anemia grade III-IV was described in 6 patients and thrombocytopenia grade III-IV in 2 patients. The median of progression free survival was 7.0 (95% CI 6.1-7.9) months. The median of overal survival was 8.4 (95 % CI 5.1-11.7) months.
Conclusion: The study demonstrated our first experience with enzalutamid in postchemo-indication in patients with mCRPC with good toleration and efficacy.
ENTIRE ARTICLE
Introduction: The aim of this retrospective study is demonstrated efficacy and tolerance of enzalutamide therapy in real clinical practice in 33 patients with metastatic castration-resistant prostate cancer (mCRPC) who had previous chemotherapy.
Patients and methods: Between November 2014 and June 2016 we treated with enzalutamide a total of 33 patients with metastatic castrate resistant prostate cancer. The all patients were previous treated by one or two lines of chemotherapy. The enzalutamide was administered by standard dose 160 mg daily.
Results: One patient had cerebral hemorrhage grade IV. In other patients the non-hematological toxicity evaluation did not achieve the grade III or IV. Anemia grade III-IV was described in 6 patients and thrombocytopenia grade III-IV in 2 patients. The median of progression free survival was 7.0 (95% CI 6.1-7.9) months. The median of overal survival was 8.4 (95 % CI 5.1-11.7) months.
Conclusion: The study demonstrated our first experience with enzalutamid in postchemo-indication in patients with mCRPC with good toleration and efficacy.