Selected articles
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Avelumab – a novelty in the treatment of patients with metastatic carcinoma of Merkel cells
06/2018 MUDr. Viera Bajčiová, CSc.
Merkel cell carcinoma (MCC) is a rare aggressive skin neuroendocrine cancer, metastatic disease is associated with poor prognosis and overal survival. The efficacy of avelumab in the JAVELIN Merkel 200 registration study in metastatic MCC refractory to chemotherapy patients and also in untreated chemotherapy naive patients with MCC resulted in its approval by the Food and Drug Administration (FDA) in the US in March 2017 and subsequently in Europe in September 2017. The administration of avelumab in advanced MCCs on both first and subsequent treatment lines has shown prolongation of the interval in both progression and overall survival and good safety profile with manageable side effects.
ENTIRE ARTICLE
Merkel cell carcinoma (MCC) is a rare aggressive skin neuroendocrine cancer, metastatic disease is associated with poor prognosis and overal survival. The efficacy of avelumab in the JAVELIN Merkel 200 registration study in metastatic MCC refractory to chemotherapy patients and also in untreated chemotherapy naive patients with MCC resulted in its approval by the Food and Drug Administration (FDA) in the US in March 2017 and subsequently in Europe in September 2017. The administration of avelumab in advanced MCCs on both first and subsequent treatment lines has shown prolongation of the interval in both progression and overall survival and good safety profile with manageable side effects.
The role and possibilities of using immunotherapy in pediatric cancer patients
05/2017 MUDr. Viera Bajčiová, CSc.
Currently the most children with cancer can be cured with standard therapy (surgery, chemotherapy, radiotherapy). The only limiting factor is its severe acute toxicity and late adverse events. In pediatric oncology immunotherapy has some delay, but the initial clinical trials of immunotherapy show a good tolerance and promising results, specially in the setting of refractory or recurrent high-risk tumors. In this article we will discuss a current situation in pediatric oncology, what immunotherapies are being tested in the clinical practice, from monoclonal antibodies, check-point inhibitors to tumor vaccines, chimeric antigene receptors, cytokines and innate immunity.
ENTIRE ARTICLE
Currently the most children with cancer can be cured with standard therapy (surgery, chemotherapy, radiotherapy). The only limiting factor is its severe acute toxicity and late adverse events. In pediatric oncology immunotherapy has some delay, but the initial clinical trials of immunotherapy show a good tolerance and promising results, specially in the setting of refractory or recurrent high-risk tumors. In this article we will discuss a current situation in pediatric oncology, what immunotherapies are being tested in the clinical practice, from monoclonal antibodies, check-point inhibitors to tumor vaccines, chimeric antigene receptors, cytokines and innate immunity.