Oral vinorelbine in the treatment of non‑small cell lung cancer – case reports

05/2018

MUDr. Lenka Jakubíková, Ph.D.

Klinika nemocí plicních a tuberkulózy LF MU Brno

SUMMARY

Vinorelbine is a second generation semisynthetic vinca alkaloid that has a low affinity for neurotubules, resulting in lower neurotoxicity. Vinca alkaloids are mitotic poisons that prevent the proper formation of microtubules by binding to tubulin. They cause depolymerization of microtubules and dissolution of the mitotic spindle, thereby blocking cell division and causing damage to other processes depending on the proper functioning of the microtubules. In oncology vinorelbine has a wider use, especially in metastatic breast cancer and non-small cell lung cancer, where it is applicable at all stages of non-adjuvant and palliative treatment.

KEY WORDS

vinorelbin, non-small cell lung cancer